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Washington University of St. Louis Postdoctoral Research Associate - Biology - 50486 in St. Louis, Missouri

Post Doc Instructions Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”. Department Name/Job Location This position is in the Department of Biology. This position is for the Danforth Campus in the School of Arts & Sciences. Essential Functions Two NIH-funded postdoctoral research positions are available immediately to study new mechanisms that regulate the microtubule severing activity of katanin and to develop a microfluidics platform to study how biochemical and biophysical mechanisms together influence microtubule array organization. The Dixit lab takes advantage of the experimentally tractable plant cortical microtubule system and uses a multidisciplinary approach to address critical questions about the inner workings of cytoskeletal structures that impact both plant and animal kingdoms. The first project focuses on how katanin activity is regulated to enable it to act as a key player in diverse cellular activities. We have obtained evidence for multiple new regulatory mechanisms that either decrease or increase katanin’s microtubule severing activity. The successful candidate will use a combination of live imaging, genetics and TIRF microscopy to dissect how these mechanisms tune katanin’s activity to achieve different cellular, developmental and physiological functions. The second project seeks a candidate interested in using microfluidics and multi-color TIRF microscopy to study how multiple microtubule regulatory factors, cell geometry and crowding work together to dynamically produce specific microtubule patterns. The goal is to use functional reconstitution experiments to identify minimal conditions that give rise to stable microtubule patterns, as well as “tipping points” that trigger network reorganization. NIH Funding is available for up to five years for each position, with the expectation that the candidates will work with Dr. Dixit to apply for fellowships during this time. Washington University in St. Louis offers a complete benefits package and competitive salary based on the NIH postdoctoral rate. Lab and university environment: The lab is a highly collegial and collaborative environment consisting of researchers pursuing a broad range of projects in the areas of cell biology, biochemistry, biophysics, and developmental biology. We have ready access to superb facilities on the main campus, Washington University School of Medicine, and the Danforth Plant Science Center. We are also part of a multi-institution NSF-funded Science and Technology Center for Engineering Mechanobiology (https://cemb.upenn.edu) that provides us access to wide-ranging expertise in biology and physical sciences. People in the lab have the freedom to pursue research that excites them and to obtain the professional and technical training needed for their career goals. Postdocs are encouraged to develop their own research projects that they can take with them. We are committed to inclusion and diversity and welcome candidates from all cultural, scientific, and socio-economic backgrounds. For more information about the lab and recent publications, please visit https://sites.wustl.edu/dixitlab/. Required Qualifications For the katanin regulation project: * Ph.D. degree in a relevant field, such as cell biology, biochemistry, biophysics, and/or genetics with demonstrated productivity in the form of publications. * Proficiency in general molecular and protein biochemistry techniques (e.g., DNA cloning, protein purification, Western blotting and co-immunoprecipitation). For the microfluidics chip platform project: * Ph.D. degree in a relevant field, such as cell biology, biochemistry, biophysics and/or biomedical engineering with demonstrated productivity in the form of publications. * Proficiency in basic protein biochemistry techniques, such as recombinant protein expression, protein purification, and Western blotting. Preferred Qualifications For the katanin regulation project: * Experience with fluorescence microscopy and quantitative image analysis will be highly preferred. * Experience with Arabidopsis plants and/or TIRF microscopy is desirable. For the microfluidics chip platform project: * Experience with soft lithography and microfluidics will be highly preferred. * Experience with TIRF microscopy is desirable. Salary Range Base pay commensurate with experience. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/. Applicant Special Instructions Interested candidates should submit their application as a single pdf file to ramdixit@wustl.edu. The application should include: 1. Cover letter detailing research interests and long-term career goals. 2. CV detailing experience and past research success. 3. Copies of relevant publications. 4. Names of three faculty references who can provide letters of recommendation upon request. EOE Statement Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. Job Title: Postdoctoral Research Associate - Biology - 50486 Job ID: 50486 Location: School of Arts & Sciences Full/Part Time: Full-Time